Vadim J. Gurvich, PhD, MBA

Research Associate Professor, Department of Medicinal Chemistry

Vadim J. Gurvich

Contact Info

vadimg@umn.edu

Office Phone 612-626-5294

Fax 612-626-6862

Office Address:
717 Delaware St SE, Room 487

Mailing Address:
Institute for Therapeutics Discovery & Development (ITDD)
717 Delaware Street SE
Room 451
Minneapolis, Minnesota 55414

Research Associate Professor, Department of Medicinal Chemistry

Associate Director, ITDD; Director, Chemical Process Development, Institute for Therapeutics Discovery and Development (ITDD)


PhD, Hebrew University of Jerusalem, 1996

MBA, University of Kansas, 2003

MS, Mendeleev University of Chemical Technology, 1987

Research

Research Summary/Interests

  • Drug discovery
  • Drug synthesis
  • Drug development
  • Synthetic organic and medicinal chemistry

Publications

  • Benyumov, A.; Gurvich, V.J.; Lis, L. G.; Williams, B.W.; Kirstein, M.N. Combinatorial pharmacologic effects for gemcitabine and metabolite dFdU. ChemMedChem 2011, 6, 457-464.
  • Rangwala, H.S.; Giraldes, J.W.; Gurvich, V.J. Synthesis and purification of [2-13C]-5-Fluorouracil. J. Label. Compd. Radiopharm. 2011, 54(6), 340-3.
  • Lis L.G.; Smart, M.A.; Luchniak, A.; Gupta, M.L.; Gurvich, V.J. Synthesis and biological evaluation of a biotinylated paclitaxel with an extra-long chain spacer arm. Med. Chem. Lett. 2012, 3, 745-8.
  • Stenland, C.J.; Lis, L. G.; Schendel, F. J.; Hahn, N. J.; Smart, M.A.; Miller, A.L.; von Keitz, M.G.; Gurvich, V.J. A Practical and Scalable Manufacturing Process for an Antifungal Agent, Nikkomycin Z. Organic Process Research & Development 2013, 17, 265-272.
  • Gurvich, V.J.; Byrn, S.R. NIPTE: a multi-university partnership supporting academic drug development. Drug Discovery Today 2013, 18, 916-921.
  • Khatri, A.; Williams, B.W.; Fisher, J.; Brundage, R.C.; Gurvich, V.J.; Lis, L.G.; Skubitz, K.M.; Dudek, A.Z.; Greeno, E.W.; Kratzke, R.A.; Lamba, J.K.; Kirstein, M.N. SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours. Br. J. Cancer 2014, 110, 304-312.
  • Dosa, P.I.; Georg, G.I.; Gurvich, V.J.; Hawkinson, J.E.; Walters, M.A.; Wong, H.L. From HTS to Phase I: The Institute for Therapeutics Discovery and Development at the University of Minnesota. Comb. Chem. High Throughput Screening 2014, 17, 231-240.