High Throughput Screening Services

submenu

High Throughput Screening

Specialized Laboratory Areas for Assay Development, Tissue Culture, High Content Image Analysis, Automated Workstations, BSL-3 Screening Facility, Sterile Automated Pipettings

Read More

Assay Capabilities

Assay Capabilities

Detection capability includes most common read modes for fluorescence and absorbance plus high content imaging, microfluidic assays and multiplexed chemiluminescence ELISA assays

  • Absorbance (endpoint, kinetic)
  • Fluorescence (endpoint, kinetic)
  • Fluorescence Resonance Energy Transfer (FRET)
  • Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)
  • Fluorescence Polarization (FP)
  • Luminescence
  • Cell based reporter & viability assays
  • High-content image analysis
  • Kinetic fluorescence imaging
  • Multiplexed chemiluminescence ELISA assays
  • Mobility-shift (electrophoretic) assays
  • Label-free binding assays
  • AlphaScreen bead-based proximity assays

Libraries for Screening

Libraries for Screening

We have a diverse small molecule screening library of over 200,000  compounds, including selected focused libraries of approved drugs, pharmacologically active molecules, kinase inhibitors, natural products, and peptidomimetics. We continue to add to our collection.

  • Sigma-Aldrich LOPAC1280
  • NIH Clinical Collection
  • TOCRIS Bioscience Tocriscreen Complete and Kinase Inhibitor Toolbox
  • Prestwick Chemical Library
  • Microsource Discovery Systems Inc. Spectrum Collection
  • ChemDiv Peptidomimetic Library and Kinase Library
  • National Cancer Institute Set
  • University of Minnesota Medicinal Chemistry Collection
  • ChemBridge MicroFormat library & MW-Set

Bioinformatics

Bioinformatics

We have industrial standard bioinformatics systems for compound registration, plate and compound management, assay SOPs, data acquisition, analysis and reporting

  • IDBS ActivityBase
  • Pipeline Pilot

Contact

Jon E. Hawkinson, Ph.D.
Director, High Throughput Screening & Assay Development Core 
Telephone: 612-626-6326 
Fax: 612-626-6862
Email: hawkinso@umn.edu