Scientific Services
▾
Research Services Focused On Small- Molecule Drug Discovery And Development
Biological and Screening Services
- High Throughput Screening
- Fragment-Based Screening
- Compound profiling for potency and selectivity
- Low and High throughput assay development and validation
- Standard biochemical assays – absorbance, luminescence, fluorescence
- Specialized biochemical assays – AlphaScreen, mobility shift, chemiluminescent ELISA
- Biophysical assays – SPR, wavelength shift, ITC
- Cell-based assays - High Content Analysis (HCA/HCS), FLIPR
- Kinases, enzymes, epigenetics, protein-protein interactions, ion channels, GPCRs
- Screening library containing 250,000 compounds
- Focused libraries and fragment libraries available for screening
- Biosafety level 3 (BSL-3) assay development and screening
Medicinal, Organic, and Process Chemistry
- Structure-Activity Relationship (SAR)
- Lead and Probe Optimization
- Parallel synthesis and chemical library production
- Total and multi-step synthesis of natural products
- Rational, protein-structure based and computational drug design
- Synthesis of lead molecules, drug candidates and advanced intermediates on a diverse scale (mg to kg)
- Chemical process development, scale-up and optimization
- Active Pharmaceutical Ingredients (API) synthesis under cGMP conditions (mg to kg) to support pre-clinical and Phases I-II clinical trials
- API stability testing
- Protein purification
Analyitcal and Purification Chemistry
- Structure identification and characterization of chemical compounds (IR, NMR [1H, 13C, 19F, 31P, COSY, NOESY, ROESY, HMBC, HMQC], HR-MS, direct infusion MS, optical rotation)
- Analytical method development (HPLC, UPLC, MS, LCMS)
- Standard Quality Control analyses (IR, MS, HPLC, UPLC, LCMS, NMR, optical rotation)
- High-throughput purification of chemical libraries
- Large scale purification of natural products
Regulatory Support (with IND/IDE Assistance Program and MCT)
- Investigational New Drug (IND) application support
- Preparation and/or revision of IND’s Chemistry, Manufacturing and Control (CMC) section for regulatory submission
Contact
Vadim J. Gurvich, Associate Director
Telephone: 612-624-4728
Fax: 612-626-6862
Email: vadimg@umn.edu